The guide
Browse the whole guide
Everything we’ve written, grouped by the three paths. Not sure where to start? Pick the door that fits you and we’ll guide you.
New to MTHFR
Start here for the calm, honest basics — what MTHFR is, and what it isn't.
MTHFR, explained without the hype
MTHFR is real — and it's also one of the most over-hyped genes on the internet. Here's the calm, honest version.
Is folic acid bad if you have MTHFR?
The most-argued question in every MTHFR group — answered calmly, without the fear. Short version: probably not the villain it's made out to be, and you have good options.
What C677T and A1298C actually mean
The two MTHFR variants everyone talks about — what your specific result (one copy, two copies, one of each) generally means, in plain, calm language.
MTHFR and pregnancy: what's real, and what's fear
MTHFR gets blamed for a lot of pregnancy worry. Here's the calm, honest picture — and the one thing that genuinely matters most.
I've been tested
You've got a result. Here's what it actually means, and what to do with it.
Nutrient forms that matter: how to actually read a label
The same vitamin can come in different forms — and the form is often what matters. A practical, no-jargon guide you can use at the supplement shelf tonight.
How to actually see your whole picture (not just one letter)
General advice can only take you so far — it can't see your genes. Here's what testing the whole methylation picture looks like, and when it's worth it.
Folate-rich foods you probably already have
Before any supplement, there's the plate. A warm, practical list of everyday folate-rich foods — and how to keep the folate in while you cook.
Supporting your family's methylation — without turning life into a science project
You don't need to turn your kitchen into a lab. A handful of calm, everyday habits do more for methylation than any amount of anxiety.
Beyond MTHFR
MTHFR is one gene of many. Explore the wider methylation genes and what each one does.
MTHFR doesn't work alone: the genes worth checking alongside it
MTHFR is one step in a bigger cycle. Looking at it next to a handful of related genes tells a far more useful story than MTHFR by itself.
The COMT gene: stress, focus, estrogen — and why it's talked about with MTHFR
COMT (and its famous Val158Met / rs4680 variant) shapes how you clear stress chemicals and estrogen. A calm, plain-English guide to what it does and why it matters.
MTR and MTRR: the B12 side of methylation
MTHFR gets the spotlight, but MTR and MTRR are the genes that actually use your B12 to finish the job. A plain-English guide to the pair — and the A66G variant.